Medical Systems Biology

The aim of our research is the development of systems biological approaches for the integrative analysis of large-scale data sets in order to elucidate pathomechanisms underlying human diseases and to understand microbial strategies of adaptation to environmental challenges. As a guiding principle we are closely interacting with clinical and experimental collaborators to analyse large-scale data sets and derive experimentally testable hypotheses from these data sets in an iterative cycle of data analysis, modelling and wet-lab experiments. Focus areas of current research include the elucidation of common mechanisms underlying human diseases (with a particular focus on aging), the development of modelling approaches that allow to study metabolic interactions within microbial communities as well as with the host and the identification of molecular mechanisms that enable pathogens to rapidly adapt to changing conditions during infection.  

Our paper with Filipe Cabreiro on the role of the microbiota in mediating the effect of Metformin was accepted in Cell.

Our paper with Hinrich Schulenburg on the functional repertoire of the C. elegans microbiota was accepted in ISME Journal.

Our paper with Philip Rosenstiel on the role of the microbiome in the treatment response to anti-TNFalpha therapy was accepted in Gastroenterology.

Group foto



We have open PostDoc, PhD student and student assistant positions.

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Research group