Medical Systems Biology

The aim of our research is the development of systems biological approaches for the integrative analysis of large-scale data sets in order to elucidate pathomechanisms underlying human diseases and to understand microbial strategies of adaptation to environmental challenges. As a guiding principle we are closely interacting with clinical and experimental collaborators to analyse large-scale data sets and derive experimentally testable hypotheses from these data sets in an iterative cycle of data analysis, modelling and wet-lab experiments. Focus areas of current research include the elucidation of common mechanisms underlying human diseases (with a particular focus on aging), the development of modelling approaches that allow to study metabolic interactions within microbial communities as well as with the host and the identification of molecular mechanisms that enable pathogens to rapidly adapt to changing conditions during infection.  

Karlis Moors joined the group as PhD student. Welcome Karlis!

Our review on the complicated environment of uncomplicated recurrent urinary tract infections with Jan Rupp is out at Frontiers in Cellular Infection Microbiology.

Our paper on the automatic reconstruction of metabolic networks for community modelling is published in Genome Biology.

Group foto



We have new openings for PostDocs, PhD students, student assistant positions and topics for Master/Bachelor thesis. 

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Research group